How Much Does Sertraline (Zoloft) Cost in Canada?

Sertraline, sold under the brand name Zoloft, is one of the most commonly prescribed antidepressants in Canada. It belongs to the selective serotonin reuptake inhibitor (SSRI) class and is used to treat depression, anxiety disorders, OCD, PTSD, and panic disorder. The cost of sertraline in Canada varies depending on whether you take the brand-name or generic version, your province, your pharmacy, and your insurance coverage. Generic sertraline is widely available and is typically the more affordable option. Without insurance, a 30-day supply of generic sertraline (50 mg) generally costs between $10 and $30 at most Canadian pharmacies. Brand-name Zoloft can cost significantly more - sometimes exceeding $80 per month. With provincial drug coverage or private insurance, your out-of-pocket cost may be substantially lower. Provincial drug plans vary. Ontario\'s Ontario Drug Benefit (ODB) program covers sertraline for eligible residents, including seniors and those receiving social assistance. British Columbia\'s PharmaCare and Alberta\'s drug coverage programs also list sertraline as a benefit. Check your provincial formulary or speak with your pharmacist. To obtain sertraline, you need a prescription from a licensed physician. This can be done through an in-person visit or a telehealth consultation. A physician will assess whether sertraline is appropriate for your situation based on your symptoms and medical history. *This article is for informational purposes only. Consult a physician before starting any medication.*

This article is for informational purposes only and does not constitute medical advice. Content reviewed by licensed Canadian physicians. Last updated February 2026.